Novobiocin-induced anti-proliferative and differentiating effects in melanoma B16
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چکیده
منابع مشابه
Effect of anti-B16 melanoma monoclonal antibody on established murine B16 melanoma liver metastases.
The administration of anti-B16 monoclonal antibody of the IgG2b isotype to mice bearing established B16 melanoma liver metastases caused a significant and consistent reduction of up to 90% in the number of these metastases. No reduction in the number of metastases was noted when antigenically unrelated tumor or nonspecific immunoglobulin were employed. The antibody-mediated antitumor effect was...
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BACKGROUND/AIMS The small GTPase of Ras and Rho families are widely involved in human tumorgenesis and metastasis. It has recently been reported that pamidronate inhibits the mevalonate pathway, which is required for the prenylation of the small GTPase. We demonstrated a possible beneficial use of pamidronate in the treatment of hepatocellular carcinoma (HCC). METHODS The effect of pamidronat...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1992
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1992.38